منابع مشابه
Evaluation of uricosuric agents in chronic gout.
Experience gained during the past 7 years with the prolonged administration of probenecid (Pascale, Dubin, and Hoffman, 1952; Talbott, 1953; Gutman and Yu, 1955; Bartels, 1955; Bauer and Singh, 1957) or of salicylates (Marson, 1953, 1954, 1955) has shown that continuous therapy with a uricosuric agent in effective doses, is the only practical method at present available for preventing the compl...
متن کاملUricosuric agents in the treatment of gout.
Kersley, Cook, and Tovey (1958) reported the therapeutic value of G.28 315 (sulphinpyrazone), a phenylbutazone derivative now known as Anturan (Geigy), in a group of fifteen patients with gout in a clinical trial lasting 3 to 8 months. Benemid and Longacid (Urelim), a benemid-like drug (Ward, Blenkinsop and Co.), were also given in selected cases. The results, as shown by estimations of the uri...
متن کاملPharmacology of uricosuric drugs.
When the level of uric acid, primarily in the form of monosodium urate (Wilcox, Khalaf, Weinberger, Kippen, and Klinenberg, 1972), exceeds the point of maximum solubility, crystals of monosodium urate may then form, particularly in the joints and connective tissues. These crystals initiate attacks of acute gout (Buchanan, Klinenberg, and Seegmiller, 1965; Seegmiller, 1965; Weissmann, 1971), and...
متن کاملUricosuric targets of tranilast
Uric acid, generated from the metabolism of purines, has both proven and emerging roles in human disease. Serum uric acid in humans is determined by production and by the net balance of reabsorption and secretion in kidney and intestine. In the human kidney, epithelial reabsorption dominates over secretion, such that in normal subjects there is at least 90% net reabsorption of filtered urate re...
متن کاملUricosuric agents in uremic sera. Identification of indoxyl sulfata and hippuric acid.
Serum and urine from chronically uremic patients and normal individuals were subjected to gel filtration of Sephadex-G10. The effects of the eluted fractions on the uptake of urate and para-aminohippurate by isolated cortical tubules of rabbit kidney were investigated. According to the origin of the samples, one to three major groups of fractions inhibiting both urate and para-aminohippurate t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1975
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780180731